Aryl Ketone Catalyzed Radical Allylation of C(sp3)–H Bonds under Photoirradiation
S. Kamijo, K. Kamijo, T. Murafuji
J. Org. Chem., 2017, 82, 2664–2671.
DOI: 10.1021/acs.joc.6b03058

Abstruct: The synthesis of alkylated pyrimidines was achieved via benzophenone-mediated photoinduced coupling between saturated heterocycles and sulfonylpyrimidines. The pyrimidine ring was selectively introduced at the nonacidic C(sp3)–H bond proximal to heteroatoms including oxygen, nitrogen, and sulfur. This is a coupling reaction mediated solely by photoexcited benzophenone, an organic molecule, without the aid of any metallic catalysts or reagents.